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. 2018 Oct 22;5:87. doi: 10.3389/fmolb.2018.00087

Figure 1.

Figure 1

DNA sliding clamps showing pseudo-hexameric symmetry and the central hole of the ring structure that accommodates double stranded DNA. (A) The Escherichia coli β-clamp dimer with one monomer colored blue and the other monomer orange. The three similar domains in each monomer are labeled Dom I, II, and III. One of the four IDCL loops is labeled. The peptide AcQADLF with its surface colored green shows the location of one of the binding pockets. The second binding pocket, notated by an arrow and dotted line is empty in this structure [PDBID: 4K30 (Zhao et al., 2013)]. (B) The human PCNA trimer with one monomer in orange, one in green and the third monomer colored blue. The two domains in one of the monomers are labeled Dom I and II. One of the three IDCLs is labeled. The FEN-1 PIP peptides are drawn in purple, with one of the ligands shown in molecular surface representation and the other two ligands as ribbons [PDBID: 1U7B (Bruning and Shamoo, 2004)]. Molecular rendering was made using Chimera (Pettersen et al., 2004).