Figure 2.

Details of the peptide binding site on β-clamp. The surface residues in subsite 1 are colored in orange and subsite 2 in cyan. Residue labels in white are for the CBM peptide and labels in black are the β-clamp binding site residues. (A) Surface representation of the peptide binding pocket and stick figure of the AcQADLF peptide bound to E. coli β-clamp [PDBID: 4K3O (Zhao et al., 2013)]. (B) Surface representation of the E. coli β-clamp peptide binding pocket with a modified peptide competitive inhibitor, Ac-Q₁Cha₂D₃L₄(3,4)ClF₅ bound in the peptide pocket [PDBID: 3Q4L (Wolff et al., 2011)]. Molecular rendering was made using Chimera (Pettersen et al., 2004).