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. 2018 Oct 22;5:87. doi: 10.3389/fmolb.2018.00087

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Copyright © 2018 Altieri and Kelman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Details of the binding site on PCNA showing ligand interactions. (A) Surface representation of FEN-1 peptide bound to human PCNA [PDBID:1U7B (Bruning and Shamoo, 2004)]. Residue labels in white refer to the FEN-1 peptide and labels in black indicate PCNA binding site residues. (B) Surface representation of the PIP binding pocket of mono-ubiquitinated human PCNA with the small molecule inhibitor, T2AA bound [PDBID: 3WGW (Inoue et al., 2014)]. This inhibitor binds 2:1 to PCNA with the second binding site at the interface between the subunits (detail not shown). Molecular rendering was made using Chimera (Pettersen et al., 2004).