Table 2. Summarized survival outcomes based on perioperative chemotherapy and cytoreduction (adapted from reference 24).
Variable | No. of studies | Mortality rate | Expected 1-year survival [%] | Expected 5-year survival [%] |
---|---|---|---|---|
Entire cohort | 20 | 0.17 (0, 0.39) | 84 [68–100] | 42 [14–100] |
EPIC used | ||||
Yes | 7 | 0.16 (0, 0.44) | 85 [64–100] | 45 [11–100] |
No | 13 | 0.19 (0, 0.55) | 83 [58–100] | 39 [6–100] |
Chemotherapy agents used | ||||
Mitomycin-C only | 1 | 0.24 | 78 | 30 |
Cisplatin only | 3 | 0.14 | 87 | 49 |
Doxorubicin + cisplatin | 3 | 0.23 | 79 | 32 |
Docetaxel + cisplatin | 1 | 0.35 | 70 | 17 |
Drug combinations including doxorubicin, mitomycin-C, cisplatin | 11 | 0.16 | 85 | 45 |
Number of patients in a study | ||||
<100 | 17 | 0.20 | 82 | 37 |
>100 | 3 | 0.15 | 86 | 47 |
Median PCI score reported | ||||
<19 | 4 | 0.16 | 85 | 45 |
>19 | 16 | 0.17 | 84 | 42 |
Median no. of patients undergoing complete cytoreduction | ||||
<50% | 6 | 0.18 | 84 | 41 |
≥50% | 14 | 0.16 | 85 | 45 |
EPIC, early postoperative intraperitoneal chemotherapy; PCI, peritoneal cancer index.