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. 2018 Jul 10;9(5):929–946. doi: 10.1002/jcsm.12315

Figure 8.

Figure 8

Exposure to glucocorticoids increases human Serpina3 expression in vitro and in vivo. Myotube diameter (A), Murf‐1 (B), Atrogin‐1 (C), and Serpina3n (D) mRNA levels in DEX‐treated and CTR human primary skeletal muscle cells SkMDC (n = 3 independent experiments). (B) Serpina3 protein levels in circulation of Cushing's and CTR patients (n = 9/group). For western‐blotting, 20 μg of proteins were loaded in each lane for each sample. Results are means ± SE. Statistical analysis was performed using unpaired t‐test (** P < 0.01, *** P < 0.001 vs. CTR). DEX, dexamethasone.