Figure 10.

Muscle‐specific deletion of mTOR induces muscle Serpina3n expression while FoxO deletion does not affect it. Serpina3n mRNA levels in tibialis anterior muscle of FoxO KO and CTR mice (A, n = 3/group), and mTOR KO and CTR mice (B, n = 3 and 5/group, respectively). Serpina3n mRNA levels (C) of C₂C₁₂ cells after 24 h of dexamethasone (10⁻⁶ M) and/or RAPA (50 nM) treatment (n = 3 independent experiments). Results are means ± SE. Statistical analysis was performed using unpaired t‐test or one‐way ANOVA and Tukey post‐test (^** P < 0.01, ^*** P < 0.001 vs. CTR, ^°°° P < 0.05 vs. RAPA, ^••• P < 0.001 vs. DEX). DEX, dexamethasone; KO, knockout.