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Clinical candidate ABX-1431 is a monoacylglycerol lipase (MGLL) inhibitor that prevents the hydrolysis of the endocannabinoid 2-arachidonoylglycerol in the human brain. It prolongs the action of 2-arachidonoylglycerol on the cannabinoid CB1 and CB2 receptors and reduces the formation of arachidonic acid, the substrate of proinflammatory prostanoids, thereby alleviating neurological symptoms and reducing neuroinflammation.
