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. 2018 Sep 19;61(20):9246–9255. doi: 10.1021/acs.jmedchem.8b00958

Figure 4.

Figure 4

LC50 concentrations (μM) for osmium complexes 113 and Pt anticancer drugs (cisplatin and carboplatin) determined in three zebrafish (Danio rerio) embryo wild-type strains: Singapore (SG), Tubingen (TU), and AB-wild type. (a) Trends in acute toxicity are maintained in all three wild-type strains of zebrafish embryo. (b) All osmium arene complexes are less toxic (higher LC50) than CDDP. See Table S5 for full numerical data.