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Canonical activating mechanism of saRNAs. A saRNA-loaded AGO2 complex binds at the target promoter and induces the open chromatin structure. The AGO2 recruits the complex of CTR9 and RHA, RNA-induced transcriptional activation (RITA), leading the transcript initiation associating with phosphorylation of RNAP II on Ser2 and H2Bub1.
