Table 1.
List of genes dysregulated following the exposure of RPTEC/TERT1 to KBrO3 for 24h compared with untreated RPTEC/TERT1 cells.
| Genes with Markedly Decreased Expression | Genes with Markedly Increased Expression | ||||
|---|---|---|---|---|---|
|
Fold
Decrease |
Gene Name | Gene |
Fold
Increase |
Gene Name | Gene |
| -57.7 | Interleukin (IL)1-receptor 1 | IL1R1 | 197.55 | Connective tissue growth factor | CTGF |
| -30.89 | Toll-like receptor 3 | TLR3 | 37.53 | Plasminogen activator inhibitor-1 | PAI1 |
| -26.57 | Chemokine (C-X-C Motif) Ligand 1 | CXCL1 | 29.92 | Resistin | RETN |
| -25 | Interleukin 8 | IL8 | 28.21 | Proto-oncogene c-Fos | FOS |
| -23.08 | Chemokine (C-X-C Motif) Ligand 2 | CXCL2 | 15.40 | Pim-3 Proto-Oncogene, Serine/Threonine Kinase | PIM3 |
| -22.29 | TNF receptor-associated factor 5 | TRAF5 | 16.24 | Suppressor of cytokine signaling 1 | SOCS1 |
| -20.26 | Signal Transducer and Activator of Transcription 1 | STAT1 | 11.66 | Tumor necrosis factor | TNFA |
| -17.5 | TNF receptor-associated factor 3 | TRAF3 | 11.28 | Toll-like receptor 4 | TLR4 |
| -17.49 | Myeloid differentiation primary response | MYD88 | 9.76 | Epidermal growth factor | EGF |
| -13.3 | TNF receptor-associated factor 6 | TRAF6 | 9.13 | Lymphotoxin-alpha | LTA |
| -12.9 | Chemokine (C-C motif) ligand 20 | CCL20 | 8.50 | Nuclear receptor related 1 protein | NR4A2 |
| -11.75 | Interleukin 6 | IL6 | 7.02 | Ubiquitin C | UBC |
| -11.59 | Caspase 1, Apoptosis-Related Cysteine Peptidase |
CASP1 | 6.18 | Adrenoceptor Beta 2, Surface | ADRB2 |
| -9.95 | B-Cell CLL/Lymphoma 3 | BCL3 | 6.55 | Interleukin-2 receptor alpha | IL2RA |
| -8.75 | Prostaglandin E Receptor 2 | PTGER2 | 4.42 | Sex Determining Region Y)-Box 9 | SOX9 |
| -8.73 | inhibitor of nuclear factor kappa-B kinase | IKBKB | 3.16 | Tumor Necrosis Factor Receptor Superfamily, Member 10b | TNFRSF10B |
| -8.35 | C-reactive protein | CRP | 3.99 | Superoxide dismutase | SOD1 |
| -7.41 | Plasminogen Activator | PLAT | 3.86 | (Early Growth Response 2 | EGR2 |
| -6.09 | Toll-like receptor 2 | TLR2 | 3.78 | C-C chemokine receptor type 10 | CCR10 |
| -5.87 | Janus Kinase 2 | JAK2 | 3.65 | Vascular cell adhesion protein 1 | VCAM1 |
| -5.57 | Mitogen-Activated Protein Kinase Kinase Kinase 1 | MAP3K1 | 3.63 | Endothelin 1 | EDN1 |
| -5.55 | Intercellular Adhesion Molecule 1 | ICAM1 | 3.54 | Jun Proto-Oncogene | JUN |
| -4.78 | Complement Component 5 | C5 | 3.38 | 26S proteasome non-ATPase regulatory subunit 3 | PSMD3 |
| -4.33 | Leukotriene B4 Receptor 2 | LTB4R2 | 3.31 | Nuclear Receptor Subfamily 4 | NR4A1 |
| -4.18 | Nuclear factor NF-kappa-B p105 | NFKB1 | 2.91 | Insulin-Like Growth Factor Binding Protein 2 | IGFBP2 |
| -4.17 | Insulin-Like Growth Factor Binding Protein 1 | IGFBP1 | 2.48 | Retinoic acid receptor alpha | RARA |
| -4.09 | Phospholipase C, Beta 4 | PLCB4 | 2.46 | Transforming growth factor beta | TGFB1 |
| -3.99 | Chemokine (C-C Motif) Ligand 2 | CCL2 | |||
| -3.98 | TNF receptor-associated factor 2 | TRAF2 | |||
| -3.83 | Signal Transducer And Activator Of Transcription 3 |
STAT3 | |||
| Genes with Markedly Decreased Expression | Genes with Markedly Increased Expression | ||||
|
Fold Decrease |
Gene Name | Gene |
Fold Increase |
Gene Name | Gene |
| -3.7 | Colony Stimulating Factor 2 Receptor | CSF2 | |||
| -3.54 | Tumor Necrosis Factor Receptor Superfamily, Member 1A | TNFRSF1A | |||
| -3.32 | CAMP Responsive Element Binding Protein 1 | CREB1 | |||
| -3.32 | Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 2 | NFKB2 | |||
| -3.16 | Insulin-Like Growth Factor Binding Protein 3 | IGFBP3 | |||
| -2.95 | Epidermal Growth Factor Receptor | EGFR | |||
| -2.84 | v-rel avian reticuloendotheliosis viral oncogene homolog | REL | |||
| -2.78 | Nuclear factor NF-kappa-B p105 subunit | NFKB1 | |||
| -2.77 | Transforming Growth Factor, Beta Receptor 1 | TGFBR1 | |||
| -2.74 | nterleukin 1 Receptor Antagonist | IL1RN | |||
| -2.43 | tumor protein p53 | TP53 | |||
| -2.35 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | MALT1 | |||
| -2.34 | V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog B | RELB | |||
| -2.09 | Mitogen-Activated Protein Kinase 8 | MAPK8 | |||