TABLE 1.
Performance of STA platforms for detection of FluA, FluB, and RSVa
| Virus and parameter | Value(s) for the following platform: |
|||||
|---|---|---|---|---|---|---|
| Fusion | Aries | Liat | Xpert | Simplexa | BioFire RP | |
| FluA | ||||||
| No. of samples with the following result: | ||||||
| TP | 75 | 74 | 75 | 74 | 74 | 75 |
| TN | 150 | 150 | 150 | 149 | 150 | 150 |
| FP | 0 | 0 | 0 | 1 | 0 | 0 |
| FN | 0 | 1 | 0 | 1 | 1 | 0 |
| % sensitivity (95% CI) | 100 (93.9–100) | 98.6 (91.7–99.9) | 100.0 (93.9–100) | 98.6 (91.7–99.9) | 98.63 (91.7–99.9) | 100 (93.9–100) |
| % specificity (95% CI) | 100 (96.8–100) | 100 (96.8–100) | 100 (96.8–100) | 99.3 (95.7 −99.9) | 100 (96.8–100) | 100 (96.8–100) |
| Subtype of sample with FN result | None | pH1N1 | None | H3N2 | H3N2 | None |
| FluB | ||||||
| No. of samples with the following result: | ||||||
| TP | 48 | 45 | 47 | 47 | 41 | 46 |
| TN | 177 | 176 | 174 | 176 | 176 | 173 |
| FP | 0 | 1 | 3 | 1 | 1 | 4 |
| FN | 0 | 3 | 1 | 1 | 7 | 2 |
| % sensitivity (95% CI) | 100 (90.7–100) | 93.7 (81.8–98.3) | 97.9 (87.5–99.8) | 97.9 (87.5–99.8) | 85.4 (71.6–93.5) | 95.8 (84.6–99.2) |
| % specificity (95% CI) | 100 (97.3–100) | 99.4 (96.4–99.9) | 98.3 (94.7–99.6) | 99.4 (96.3–99.9) | 99.4 (96.4–99.9) | 97.7 (93.9–99.2) |
| Subtype of sample with FN result (no. of strains) | None | Yamagata (3) | Yamagata | Yamagata | Yamagata (5), Victoria (2) | Yamagata (2) |
| RSV | ||||||
| No. of samples with the following result: | ||||||
| TP | 52 | 51 | 53 | 53 | 47 | 51 |
| TN | 171 | 171 | 170 | 170 | 170 | 171 |
| FP | 0 | 0 | 1 | 1 | 1 | 0 |
| FN | 2 | 3 | 1 | 1 | 7 | 3 |
| % sensitivity (95% CI) | 96.3 (86.2–99.3) | 94.4 (83.6–98.5) | 98.1 (88.8–99.9) | 98.1 (88.8–99.9) | 87 (74.5–94.2) | 94.4 (83.6–98.5) |
| % specificity (95% CI) | 100 (97.2–100) | 100 (97.2–100) | 99.4 (96.3–99.9) | 99.4 (96.3–99.9) | 99.4 (96.3–99.9) | 100 (97.2–100) |
| Subtype of sample with FN result | Not performed | Not performed | Not performed | Not performed | Not performed | Not performed |
a
TP, true positive; TN, true negative; FP, false positive; FN, false negative; CI, confidence interval.