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. 2018 Sep 21;86(10):e00360-18. doi: 10.1128/IAI.00360-18

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Copyright © 2018 Norris et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 8 — Inflammasome activation, invasion, and intracellular replication by lpxO and pagL mutants. (A) Cytotoxicity measurements following intracellular infection of unprimed or Salmonella LPS-primed RAW264.7 murine macrophages. White bars represent unprimed macrophage cytotoxicity levels, and gray bars represent cytotoxicity levels of macrophages treated exactly the same but primed overnight with Salmonella LPS. Data are the mean and standard deviation of the results of one representative experiment carried out in triplicate. Significance was determined by one-way ANOVA to the 1026b wild type (WT). (B) Invasiveness of 1026b and the lpxO and pagL mutants and complements (COMP) in RAW264.7 murine macrophages. (C) Replication of 1026b wild-type bacteria compared to that of the lpxO and pagL mutants and their complements at 2 and 24 h postinfection. Data shown are the mean and standard deviation of the results of one of two independent experiments carried out in triplicate. Significance was determined by one-way ANOVA comparison to 1026b WT or as indicated by horizontal bars. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.