Table 4.
List of compounds that were deemed astro-toxic, using ‘cell density at time of compound application’ as a baseline.
| Astro-Toxic Compound | Categorization | Cell Density relative to 2 Day | HIT? | MTT-Based Astro-toxic by Pei et al |
|---|---|---|---|---|
| Methyl mercuric (II) chloride | DNT/NT | 0.0 | YES | YES (100 μM) |
| Bis(tributyltin)oxide | DNT/NT | 0.0 | YES | NO |
| Valinomycin | Other | 21.7 | YES | YES (100 μM) |
| Colchicine | DNT/NT | 47.8 | YES | YES (100 μM) |
| 2-Methyoxyethanol | DNT/NT | 74.5 | YES | YES (10 and 100 μM) |
| Benzo(b)fluoranthene | PAH | 79.6 | YES | NO |
| Berberine chloride | Other | 80.9 | YES | NO |
| Negative Controls | ||||
| Acetaminophen | NC | 150.3 | NO | YES (100 μM) |
| L-Ascorbic acid | NC | 143.9 | NO | YES (10 and 100 μM) |
| D-Glucitol | NC | 138.2 | NO | YES (100 μM) |
| Acetylsalicylic acid | NC | 148.4 | NO | YES (100 μM) |
| Saccharin Sodium Salt hydrate | NC | 136.3 | NO | NO |
The cell density of individual wells treated with corresponding compounds is listed. This compiles all the compounds from the library that were categorized as astro-toxic, as well as compounds originally included in the library as negative controls for neurotoxicity.