Table 4.

Relative Gene Expression (RQ Value ± SD) in Kidneys for Experiments Using 23 UOG Chemicals Using L13 as Endogenous Control Gene

Genes	Uninfecteda	p values	FV3 infectedb	p values (3 dpi)	p values 3 dpi/Uninfc
Arg I	C: 5 ± 1		C: 115 ± 66		C: NS
	L: 598 ± 330	NS	L: 2343 ± 962	0.02*	L: NS
	H: 147 ± 84	NS	H: 157 ± 70	NS	H: NS
CSF-1	97 ± 32		C: 3922 ± 2326		C: NS
	17 ± 8	NS	L: 58 ± 26	NS	L: NS
	2670 ± 1717	NS	H: 2610 ± 658	NS	H: NS
GCSFR	C: 72 ± 29		C: 366 ± 127		C: 0.04*
	L: 107 ± 57	NS	L: 160 ± 118	NS	L: NS
	H: 332 ± 103	0.04*	H: 215 ± 100	NS	H: NS
IFN type I	C: 25 ± 12		C: 1617 ± 501		C: 0.005*
	L: 85 ± 30	NS	L: 553 ± 404	NS	L: NS
	H: 14 ± 4	NS	H: 88 ± 37	0.02*	H: NS
IFN type II (γ)	C: 116 ± 47		C: 1185 ± 645		C: NS
	L: 20 ± 10	NS	L: 64 ± 27	NS	L: NS
	H: 64 ± 25	NS	H: 53 ± 15	NS	H: NS
IFN type III (λ)	C: 79 ± 42		C: 702 ± 330		C: NS
	L: 2357 ± 1961	NS	L: 829 ± 516	NS	L: NS
	H: 146 ± 83	NS	H: 296 ± 144	NS	H: NS
IL-1β	C: 170 ± 73		C: 7271 ± 3160		C: 0.04*
	L: 167 ± 127	NS	L: 363 ± 283	0.03*	L: NS
	H: 60 ± 21	NS	H: 190 ± 85	0.03*	H: NS
IL-10	C: 25 ± 17		C: 135 ± 58		C: NS
	L: 67 ± 43	NS	L: 81 ± 49	NS	L: NS
	H: 30 ± 10	NS	H: 37 ± 16	NS	H: NS
IL-34	C: 13 ± 4		C: 37 ± 22		C: NS
	L: 26 ± 11	NS	L: 91 ± 64	NS	L: NS
	H: 83 ± 19	0.002*	H: 78 ± 29	NS	H: NS
CSF-R1	C: 21 ± 7		C: 165 ± 80		C: NS
	L: 79 ± 40	NS	L: 64 ± 37	NS	L: NS
	H: 44 ± 16	NS	H: 15 ± 6	NS	H: NS
Mx1	C: 35 ± 17		C: 3931 ± 1289		C: 0.007*
	L: 23 ± 11	NS	L: 4480 ± 3479	NS	L: NS
	H: 647 ± 341	NS	H: 31 719 ± 13801	NS	H: 0.04*
TNFα	C: 22 ± 8		C: 909 ± 578		C: 0.05*
	L: 21 ± 12	NS	L: 62 ± 42	NS	L: NS
	H: 235 ± 57	0.001*	H: 965 ± 413	NS	H: NS

NS, nonsignificant; *,significant.

^aGene expression RQ values from kidneys of tadpoles (10 per group) treated with 0.2% EtOH, 0.1 μg/l (L), or 1 μg/l (H) of UOG mixture for 3 weeks using L13 as reference gene. p value determined between vehicle control and treated animals.

^bGene expression RQ values from kidneys of tadpoles (10 per group) treated with 0.2% EtOH, 0.1 μg/l (L), or 1 μg/l (H) of UOG mixture then FV3 infected for 3 days using L13 as reference gene. p value determined by between vehicle control and treated animals.

^cp value determined between each treated and corresponding infected group.