Table 3.

Model predicted versus observed TAb, ac-dmDNA31, and uc-dmDNA31 concentrations in non-infected mouse plasma following a single IV dose of 50 mg/kg DSTA4637A.

	TAb (µg/ml)			ac-dmDNA31 (ng/ml)			uc-dmDNA31 (ng/ml)
Time (day)	Observed1	Predicted	Ratio2	Observed1	Predicted	Ratio2	Observed1	Predicted	Ratio2
0.00694	1223 ± 32	1280	1.05	11978 ± 798	15896	1.33	1.31 ± 0.19	0.311	0.24
0.0417	988 ± 104	1224	1.24	10051 ± 1005	15123	1.50	0.734 ± 0.028	1.62	2.21
0.25	694 ± 27	944	1.36	7394 ± 282	11338	1.53	0.699 ± 0.207	4.46	6.38
1	494 ± 30	479	0.97	4088 ± 304	5184	1.27
2	451 ± 56	320	0.71	3487 ± 219	3016	0.86
3	374 ± 25	266	0.71	2240 ± 23	2179	0.97
7	308 ± 29	208	0.68	1091 ± 57	977	0.90
10	273 ± 22	189	0.69	678 ± 37	584	0.86
14	216 ± 31	168	0.78	311 ± 14	296	0.95

¹Observed values are presented as mean ± SD.

²Ratio = Predicted: observed.