Table 3. The EC50, CC50 and SI values from extracts that inhibited influenza A replication higher than 80% in screening assay.
| Extract | Taxon | EC50a(µg/mL) | CC50b(µg/mL) | SIc | ||
|---|---|---|---|---|---|---|
| A(H1N1)pdm09-WT | A(H3N2)-WT | A(H1N1)pdm09-WT | A(H3N2)-WT | |||
| 1 | Unidentified filamentous green algae | 130 | 150 | >1,000 | >7.7 | >6.7 |
| 2 | Staurastrum sp. | 70 | 90 | >1,000 | >14.3 | >11.1 |
| 4 | Scenedesmus sp. | 130 | 130 | >1,000 | >7.7 | >7.7 |
| 5 | Leptolyngbya sp.d | 80 | 85 | >1,000 | >12.5 | >11.8 |
| 18 | Desmodesmus armatus | 55 | 60 | >1,000 | >18.4 | >16.7 |
| 21 | Chlorellaceae | 30 | 40 | >1,000 | >33.3 | >25.0 |
| 24 | Desmidiaceae | 50 | 55 | >1,000 | >20.0 | >18.2 |
| OST-car | 0.012 µM | 0.032 µM | 2,132 µM | 177,7 | 66,63 | |
Notes.
a
EC50, the concentration required to reduced inhibition of viral infection-induced cytopathogenicity by 50%. Values represent the mean of duplicate samples from three independent experiments.
b
CC50, the concentration required to reduced normal, non-infected cell viability by 50%. Values represent the mean of duplicate samples from three independent experiments.
c
SI, selective index is determined by the ratio between CC50 and EC50.
d
Cyanobacteria strain.
- OST-car
- OST carboxylate