Table 4. The EC50 and IC50 values from extracts for OST-sensitive and resistant influenza A and B viruses.
| Influenza Virus strain | EC50a(µg/mL) | IC50b(µg/mL) | |||
|---|---|---|---|---|---|
| Leptolyngbyasp.(extract 5) | Chlorellaceae (extract 21) | Leptolyngbyasp.(extract 5) | Chlorellaceae (extract 21) | OST-car (nM) | |
| A(H1N1)pdm09-WT | 80 | 30 | 149 ± 5 | 16 ± 2 | 0.1 ± 0.2 |
| A(H3N2)-WT | 85 | 40 | 162 ± 3 | 14 ± 3 | 2.1 ± 0.3 |
| A/Perth/261/2009 (A(H1N1)pdm09H275Y) | 168 | 50 | 208 ± 4 | 72 ± 3 | 112 ± 2 |
| B/Phuket/3073/2013 Yam (WT) | 215 | 70 | 207 ± 5 | 68 ± 2 | 2.8 ± 1 |
| B/Brisbane/60/2008 Vic (WT) | 230 | 75 | 199 ± 4 | 41 ± 2 | 3 ± 0.5 |
| B/Perth/211/2001 Yam (WT) | 200 | 100 | 179 ± 3 | 30 ± 5 | 5.0 ± 1 |
| B/Perth/211/2001 Yam (D197E) | 260 | 120 | 184 ± 5 | 42 ± 4 | 10 ± 2 |
Notes.
a
EC50, the concentration required to reduced inhibition of viral infection-induced cytopathogenicity by 50%. Values represent the mean of duplicate samples from three independent experiments.
b
IC50, the concentration required to inhibit 50% of the NA enzymatic activity. Values represent the mean of duplicate samples from three independent experiments ± standard error.
- OST-car
- OST carboxylate