Table 1.
Demographic and baseline characteristics of chronic hepatitis C patients vs controls
| Variables | Patients (n=75) | Controls (n=40) | P-values |
|---|---|---|---|
| Age (years), mean±SD (range) | 47±12 (20–67) | 43.75±13.7 (20–66) | 0.879 |
| Gender (male/female) | 48/27 (64%/36%) | 28/12 (70%/30%) | 0.778 |
| BMI (kg/m2), mean±SD (range) | 22.28±1.9 (16–25) | 21.8±1.79514 (18–26) | 0.457 |
| Waist/hip ratio, mean±SD (range) | 0.93±0.019 (0.9–0.97) | 0.9345±0.01 (0.89–0.98) | 0.277 |
| Hemoglobin (g/dL), mean±SD (range) | 13.6±1.3 (10–17) | 13.78±1.4 (10–17) | 0.01 |
| Platelets (×109), mean±SD (range) | 194.4±58 (81–430) | 222.98±38.2 (156–322) | 0.001 |
| Albumin (g/L), mean±SD (range) | 3.7±0.6 (2.1–5.4) | 4.3±0.25 (4–4.9) | 0.05 |
| INR, mean±SD (range) | 1.1±0.1 (0.9–1.4) | 1.05±0.061 (1.00–1.10) | 0.001 |
| Creatinine (mg/L) | 0.94±0.18 (0.64–1.6) | 0.894±0.15 (0.64–1.27) | 0.219 |
| Mean total bilirubin (mg/dL) | 0.85±0.48 (0.1–1.2) | 0.5±0.22 (0.1–1.1) | 0.02 |
| Mean ALT (IU/L), mean±SD (range) | 50.1±20.0 (21–103) | 21.78±8.16 (13–37) | 0.001 |
| Mean AST (IU/L), mean±SD (range) | 50.8±25.8 (17–163) | 20.12±5 (12–40) | 0.001 |
| Cholesterol (mg/dL), mean±SD (range) | 143.6±29 (70–195) | 137±30 (80–210) | 0.279 |
| Mean triglycerides (mg/dL), mean±SD (range) | 98±30.8 (35–225) | 103.15±27.15 (70–140) | 0.371 |
| LDL-c (mg/dL), mean±SD (range) | 84±38 (11–131) | 79.6±33.7 (25–161) | 0.49 |
| HDL-c (mg/dL), mean±SD (range) | 42.1±5.8 (31–58) | 40.8±5.3 (31–51) | 0.07 |
| AFP (ng/mL), mean±SD (range) | 3.6±3.8 (0.7–32.8) | – | – |
| Mean viral load(log10), mean±SD (range) | 5.2±1.3 (2.04–7.9) | – | – |
| Fibrosis stage (Fibroscan) | |||
| F0, n (%) | 2 (2.5) | – | – |
| F1, n (%) | 13 (16.3) | ||
| F2, n (%) | 23 (30.3) | ||
| F3, n (%) | 16 (20.1) | ||
| F4, n (%) | 21 (27.6) | ||
| F0, F1, F2, F3, F4, ranges, n (%) | 38–37 (43.5%–56.5%) | ||
| FIB-4, mean±SD | 1.9±1.1 | – | – |
Abbreviations: –, not evaluated; AFP, alpha fetoprotein; ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; FIB-4, Fibrosis-4 Index for Liver Fibrosis; HDL-c, high-density lipoprotein cholesterol; INR, international normalized ratio; LDL-c, low-density lipoprotein cholesterol.