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. 2018 Oct 23;13:6677–6688. doi: 10.2147/IJN.S179290

Figure 2.

Figure 2

MDA-MB-453 growth monitoring on 3D spheroids models. Spheroids were seeded with 1,500 cells (A, C) or 4,000 cells (B) and treated with free docetaxel + free trastuzumab, liposomes + free trastuzumab, immunoliposomes, or T-DM1 at low concentration (ie, [docetaxel] =2 nM, [trastuzumab] =4 pM, and [T-DM1] =3.25 ng/mL) and high concentration (ie, [docetaxel] =8 nM, [trastuzumab] =16 pM, and [T-DM1] =13 ng/mL), at day 3 and day 10 (A, B) or day 6 and day 13 (C).a

Notes: aValues are mean ± SEM of three or more experiments. The square brackets refer to the concentration.

Abbreviations: SEM, standard error of the mean; 3D, three-dimensional; T-DM1, ado-trastuzumab emtansine; MDA-MB, derived from metastatic site: mammary breast; Ab, trastuzumab.