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. 2018 Oct 23;13:6717–6733. doi: 10.2147/IJN.S173702

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© 2018 Koch et al. This work is published and licensed by Dove Medical Press Limited

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Testing cytocompatibility of monomeric P11-SAP solution and extracts of P11-SAP hydrogels in HPDLF.

Notes: (A) Metabolic activity of HPDLF exposed for 24 hours with the P11-SAP monomers (concentrations: 1 and 5 mg/mL, PrestoBlue^® Cell Viability Reagent, in percent compared with untreated control, n=3, *P≤0.01). (B) Cell amount of HPDLF cells exposed to extraction products of different P11-SAP hydrogels (after 24 hours, 1, 5, and 10 mg/mL, in percent compared with untreated control, n=3, *P≤0.01, determined by crystal violet staining) and (C) LDH release of HPDLF cells exposed to extraction products of P11-SAP hydrogels (after 24 hours, 1, 5, and 10 mg/mL, in percent compared with untreated control, n=3, *P≤0.01, measured with LDH cytotoxicity test kit).

Abbreviations: HPDLF, human periodontal ligament fibroblast; LDH, lactate dehydrogenase; P11-SAP, 11-amino acid self-assembling peptide.