Figure 2.

Hit confirmation. A, inhibitory activity of resynthesized GRP-156784 against different luciferase reporter viruses (red y axis), standard RSV A2-L19F (blue y axis), and measurements of cellular metabolic activity of uninfected cells exposed to the compound (black y axis). Where applicable, active concentrations were calculated through four-parameter variable slope regression modeling; values in parentheses denote 95% confidence intervals). B, anti-RSV activity and cytotoxicity of resynthesized GRP-156784 in primary HBTECs. Symbols in A and B represent biological repeats (n = 3 each or greater); error bars, S.D.