TABLE 1.

Metabolic stability testing of first- and second-generation lead candidates

¹ Predicted solubility is shown as the average of three solubility predictions taken from SwissADME: ESOL (58), Ali (57), and SILICOS-IT.

² Metabolic susceptibility scores were determined by calculating the sum of the predicted metabolic susceptibility probabilities for all atoms in the molecule, giving an overall score of metabolic susceptibility. Lower scores are predicted to be less suceptibile to CYP metabolism.