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Amino acid alignment in helix 3 of the first transmembrane domain of SSD and RND proteins. Shown are the amino acid sequences for the SSD-containing proteins Ptch1, Ptch2, dPtc, NPC1, PtchD1, PtchD4, Disp, and SCAP as well as the RND proteins AcrB, CnrA, and p695. Two critical residues that are different in NPC1 and lead to Gorlin syndrome when altered in hPtch1 are indicated with circles.
