Figure 3.

Solution structure of the CARD9–CARD in the Zn²⁺-bound state. A, two lowest energy Zn²⁺-bound CARD9–CARD structures, demonstrating Zn²⁺ coordination by Cys-10, His-73, and Asp-7. B, alignment of the 20 lowest energy structures of the CARD9–CARD in the apo (black) and Zn²⁺-bound (red) states.