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ins (oe) functions on L1 arrest life span. A, daf-18/pten mutants have shorter L1 arrest life span and the insulin receptor daf-2 mutants have a longer L1 arrest life span than WT worms. B and C, 21 ins (oe) strains have shorter L1 life span, suggesting these INS are IIS agonists. D, 8 ins (oe) strains have longer L1 life span, suggesting these INS peptides are IIS antagonists. Also see details in Table S2.
