Table 1.
Determination of the MIC of anti-TB drugs
The anti-mycobacteria activity/effect of the anti-TB drugs was measured by the REMA. The results were carried out with three independent biological replicates. MIC for M. tuberculosis H37Ra/pMV261-etbR is significantly different (p < 0.001, two-tailed Student's t test) between INH and INH + 0.2 μg/ml EMB.
| Drugs | MIC (μg/ml) |
||||
|---|---|---|---|---|---|
| M. tuberculosis H37Ra/pMV261 | M. tuberculosis H37Ra/pMV261-etbR | BCG/pMindD | BCG/etbR::hyg/ pMindD | BCG/etbR::hyg/ pMindD-etbR | |
| INH | 0.025 | 0.0125 | 0.025 | 0.05 | 0.025 |
| EMB | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 |
| INH (+0.2 EMB) | 0.0125 | 0.003125 | 0.0125 | 0.05 | 0.0125 |