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. 2018 Sep 14;293(43):16546–16558. doi: 10.1074/jbc.RA118.004929

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© 2018 Ghovanloo et al.

Author's Choice—Final version open access under the terms of the Creative Commons CC-BY license.

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Figure 6. — CBD inhibits human iPSC neuronal Nav and Kv currents. A, concentration-response relationship for CBD inhibition of hNav1.2 channels obtained using manual patch clamp (IC₅₀ = 1.3 ± 0.1 μm, slope = 2.1 ± 0.4, n = 3–6). B, plot of normalized SSFI after a 100 ms prepulse before (V_½ = −50.0 ± 0.4 mV, slope = 6.4 ± 0.4, n = 3) and after (V_½ = −66.1 ± 0.7 mV, slope = 8.1 ± 0.6, n = 3) perfusion. C, open-state fast-inactivation time constants shown on log scale on the y axis at −20 mV for vehicles (−20 mV: 1.3 ± 0.1 ms, n = 3) and CBD (−20 mV: 1.3 ± 0.4 ms, n = 3) in iPSC neurons. D and E, representative current-voltage relationship recorded from iPSC neurons with a KF based internal solution before 1 μm perfusion of CBD (D) and after perfusion (E). Insets in the panel are zoomed-in view of currents at the test pulse used to assess availability.