. 2018 Sep 14;293(43):16546–16558. doi: 10.1074/jbc.RA118.004929

Table 1.

The comparison of CBD to phenytoin and carbamazepine

Parameter	Cannabidiol	Phenytoin	Carbamazepine
Brain–lipid binding–TRANSIL (%)	99.6	98.5	83.7
Plasma–protein binding (%)	∼95–99^a	95^a	∼70^a
IC₅₀ on Nav channels (μm)	1–4	∼10^a	∼25^a
ED₅₀ MES (mg/kg)	∼120^a	8.2–17.5^a	7.5^a
Efficacious plasma level (μm)	6.4–8.3^a	4–10^a	5–12^a
Brain concentration (μm)	21.9^a	86^a	9.7^a
Brain/IC₅₀ (ratio)	5.5–21.9	8.6	0.4

^a These parameters were taken from literature (5, 6, 39, 41 –48, 57 –59).