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. 2018 Mar 21;67(8):1543–1552. doi: 10.1136/gutjnl-2018-316029

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Guanylate cyclase-C (GC-C) functional overlap with numerous symptoms found in GI disorders. Research on various GI disorders has elucidated the importance of the GC-C receptor and the physiological pathways in which it is involved. Dysregulation of the GC-C–cGMP signalling axis has been associated with dysfunction in the mucosal barrier (eg, UC); fluid and electrolyte balance and pH regulation (eg, chronic idiopathic constipation, IBS with constipation); and epithelial cell proliferation, migration, differentiation and apoptosis (eg, colorectal cancer). These pathways contribute to the abdominal symptoms and/or inflammation involved in GI diseases.