Figure 4.

CF complications, 2014 ivacaftor and comparator cohorts, (A) US CFFPR and (B) UK CFR Direct comparisons between the US and the UK data on the prevalence of complications cannot be made because of the differences in complication screening and data capture between countries. ^aIncludes distal intestinal obstruction syndrome, fibrosing colonopathy/colonic stricture, gastro-oesophageal reflux disease, gastrointestinal bleed (non-variceal) requiring hospitalisation, peptic ulcer disease and rectal prolapse. ^bIncludes allergic bronchopulmonary aspergillosis, asthma, massive haemoptysis and pneumothorax requiring a chest tube. ^cIncludes arthritis/arthropathy, bone fracture, osteopaenia and osteoporosis. ^dThe US CFFPR includes gallstones, gallstones requiring surgery/procedure, liver disease (cirrhosis), cirrhosis complications (oesophageal varices, gastric varices, gastrointestinal bleed, splenomegaly, hypersplenism and ascites), liver disease (non-cirrhosis), hepatic steatosis and liver disease (other); the UK CFR also includes abnormal liver enzymes. CF, cystic fibrosis; CFFPR, Cystic Fibrosis Foundation Patient Registry; CFR, Cystic Fibrosis Registry; CFRD, cystic fibrosis-related diabetes; RR, relative risk.