Table 3.
Results of Point-of-Care Testing for Detection of Toxoplasma IgG/IgM per Toxoplasma Infection Status
| POC Kit |
Toxoplasma Antibodies | POC Result | Toxoplasma Infection Status | ||
|---|---|---|---|---|---|
| Acute Infection (IgG+/IgM+) n = 85a (%) |
Chronic Infection (IgG+/IgM−) n = 85 (%) |
Seronegative (IgG−/IgM−) n = 80 (%) |
|||
| Biopanda |
IgG | Positive | 85 (100) | 85 (100) | 3 (3.8) |
| Negative | 0 (0) | 0 (0) | 77 (96.3) | ||
| IgM | Positive | 51 (62.2) | 16 (18.9) | 3 (3.8) | |
| Negative | 31 (37.8) | 69 (81.1) | 77 (96.2) | ||
| OnSite |
IgG | Positive | 85 (100) | 85 (100) | 2 (2.5) |
| Negative | 0 (0) | 0 (0) | 78 (97.5) | ||
| IgM | Positive | 23 (28.0) | 3 (3.5) | 1 (1.3) | |
| Negative | 59 (72.0) | 82 (96.5) | 79 (98.7) | ||
| LDBIO |
IgG/IgM Combined |
Positive | 85 (100) | 85 (100) | 1 (1.3) |
| Negative | 0 (0) | 0 (0) | 79 (98.7) | ||
Abbreviations: CDC, Centers for Disease Control and Prevention; CDC-HSP, CDC Toxoplasma 1998 Human Serum Panel; ELISA, enzyme-linked immunosorbent assay; IgG, immunoglobulin; PAMF-TSL, Palo Alto Medical Foundation, Toxoplasma Serology Laboratory; POC, point of care.
a Three of 85 samples (from the CDC-HSP 1998) were excluded from the calculation of analytical sensitivity for IgM that were provided to us by the CDC report, because PAMF-TSL IgM-ELISA results were <2.0 units (cutoff for positive).