Figure 3.

The effects of paraspeckle destruction on HCC cell invasion, proliferation and apoptosis under IL-6 stimulation.

(A) The invasive ability of QGY-7703/HepG2 HCC cells was evaluated by in vitro invasion assay after transfection of NC, si-NEAT1_2 or si-NONO with or without IL-6 stimulation for 48 h (*p < 0.05). (B) Cell cycle was analyzed by flow cytometry when HCC cells were transfected of NC, si-NEAT1_2 or si-NONO with or without IL-6 stimulation for 48 h (*p < 0.05). (C) Apoptotic QGY-7703 or HepG2 cells were analyzed by flow cytometry after transfection of NC, si-NEAT1_2 or si-NONO and stimulation with or without IL-6 for 24 h and later stimulated by cis-platinum for 24 h (*p < 0.05).