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. 2018 Aug 6;7(11):e1503913. doi: 10.1080/2162402X.2018.1503913

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Figure 4. — Paraspeckle destruction inhibits IL-6-induced STAT3 phosphorylation.

Phosphorylation of STAT3 and total STAT3 were analyzed by Western blotting in (A) QGY-7703 cells or (B) HepG2 cells transfected with si-NEAT1_2 or si-NONO with IL-6 stimulation as indicated time. (C) mRNA expression of Bcl-2, c-myc and Mmp-2 was measured in QGY-7703 cells transfected with si-NEAT1_2 or si-NONO with IL-6 stimulation for indicated time (*p < 0.05). (D) Protein expression of Bcl-2, c-myc and Mmp-2 were measured in QGY-7703 cells transfected with si-NEAT1_2 or si-NONO with IL-6 stimulation for 24 h. (E) mRNA expression of Bcl-2, c-myc and Mmp-2 were measured in HepG2 cells transfected with si-NEAT1_2 or si-NONO with IL-6 stimulation for indicated time (*p < 0.05). (F) protein expression of Bcl-2, c-myc and Mmp-2 were measured in HepG2 cells transfected with si-NEAT1_2 or si-NONO with IL-6 stimulation for 24 h.