Table 1.
TIM-3+ iTILs association with clinico-pathological parameters in breast cancer.
| Parameters | Negative N = 2816 |
TIM-3+ iTILs ≥ 1 N = 332 (11%) |
P-value* (χ2) |
|---|---|---|---|
| Age at diagnosis (years) | |||
| < 50 | 787 | 119 (13%) | 0.003 |
| ≥ 50 | 2029 | 213 (10%) | |
| Tumor size (cm) | |||
| ≤ 2 | 1467 | 163 (10%) | 0.331 |
| > 2 | 1334 | 166 (11%) | |
| Grade | |||
| 1&2 | 1286 | 96 (7%) | < 0.001 |
| 3 | 1414 | 219 (13%) | |
| Unknown | 116 | 12 | |
| Ki67 | |||
| Negative (< 14%) | 1469 | 100 (6%) | < 0.001 |
| Positive (≥ 14%) | 1085 | 209 (16%) | |
| Unknown | 262 | 23 | |
| ER | |||
| Negative | 716 | 159 (18%) | < 0.001 |
| Positive (> 1%) | 2091 | 172 (8%) | |
| Unknown | 9 | 1 | |
| Subtypes | |||
| Luminal A | 1209 | 73 (6%) | < 0.001 |
| Luminal B | 631 | 80 (11%) | |
| HER2E | 184 | 25 (12%) | |
| Basal-like | 205 | 81 (28%) | |
| Triple negative, non-basal | 182 | 40 (18%) | |
| Unknown | 240 | 17 |
* Chi-square test