Table 3.

Results of subgroup analysis in terms of stage, cutoff value, timing, and region.

Outcome or Subgroup	Studies	Statistical Method	Effect Estimate
OS and stage	8	Hazard Ratio (IV, Random, 95% CI)	1.75 [1.33, 2.30]
Other	1	Hazard Ratio (IV, Random, 95% CI)	1.09 [1.04, 1.14]
Advanced stage	7	Hazard Ratio (IV, Random, 95% CI)	1.77 [1.50, 2.09]
PFS and stage	10	Hazard Ratio (IV, Random, 95% CI)	1.44 [1.18, 1.77]
OS and cutoff value	8	Hazard Ratio (IV, Random, 95% CI)	1.77 [1.35, 2.32]
< 5	3	Hazard Ratio (IV, Random, 95% CI)	1.59 [0.83, 3.07]
≥ 5	6	Hazard Ratio (IV, Random, 95% CI)	1.76 [1.47, 2.10]
PFS and cutoff value	10	Hazard Ratio (IV, Random, 95% CI)	1.44 [1.18, 1.77]
< 5	4	Hazard Ratio (IV, Random, 95% CI)	1.19 [1.00, 1.41]
≥ 5	6	Hazard Ratio (IV, Random, 95% CI)	1.73 [1.14, 2.62]
OS and timing	8	Hazard Ratio (IV, Random, 95% CI)	1.81 [1.42, 2.32]
Baseline	8	Hazard Ratio (IV, Random, 95% CI)	1.75 [1.33, 2.30]
Post-treatment	2	Hazard Ratio (IV, Random, 95% CI)	2.26 [1.05, 4.86]
PFS and timing	10	Hazard Ratio (IV, Random, 95% CI)	1.69 [1.34, 2.14]
Baseline	10	Hazard Ratio (IV, Random, 95% CI)	1.44 [1.18, 1.77]
Post-treatment	3	Hazard Ratio (IV, Random, 95% CI)	3.17 [1.48, 6.82]
OS and region	8	Hazard Ratio (IV, Random, 95% CI)	1.75 [1.33, 2.30]
Asian	2	Hazard Ratio (IV, Random, 95% CI)	1.61 [1.41, 1.84]
Europe	2	Hazard Ratio (IV, Random, 95% CI)	3.83 [1.86, 7.89]
American	4	Hazard Ratio (IV, Random, 95% CI)	1.65 [1.07, 2.57]
PFS and region	10	Hazard Ratio (IV, Random, 95% CI)	1.44 [1.18, 1.77]
Asian	4	Hazard Ratio (IV, Random, 95% CI)	1.20 [0.84, 1.72]
Europe	3	Hazard Ratio (IV, Random, 95% CI)	2.31 [0.95, 5.60]
American	3	Hazard Ratio (IV, Random, 95% CI)	1.60 [1.25, 2.03]

Abbreviation: OS, overall survival; PFS, progression free survival; CI, confidence interval.