Table 1.
Baseline Demographics and Comorbidities in the Year Before Initial UF Procedure
| Myomectomy (of known type) | Abdominal myomectomy | Hysteroscopic myomectomy | Laparoscopic myomectomy | EA | UAE | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| n = 13,804 | n = 8,018 | n = 941 | pa | n = 4,845 | pa | n = 17,198 | pb | n = 4,629 | pb | |
| Demographics | ||||||||||
| Mean age (SD) | 37.0 (5.6) | 36.5 (5.3) | 41.0 (6.0) | <0.001 | 37.0 (5.7) | <0.001 | 42.4 (5.0) | <0.001 | 42.9 (4.5) | <0.001 |
| 18–29, n (%) | 1,225 (8.9) | 730 (9.1) | 39 (4.1) | <0.001 | 456 (9.4) | 0.560 | 284 (1.9) | <0.001 | 36 (0.9) | <0.001 |
| 30–34, n (%) | 3,483 (25.2) | 2,148 (26.8) | 118 (12.5) | <0.001 | 1,217 (25.1) | 0.037 | 1,053 (6.1) | <0.001 | 204 (4.4) | <0.001 |
| 35–39, n (%) | 4,546 (32.9) | 2,816 (35.1) | 179 (19.0) | <0.001 | 1,551 (32.0) | <0.001 | 3,037 (17.7) | <0.001 | 745 (16.1) | <0.001 |
| 40–44, n (%) | 3,164 (22.9) | 1,772 (22.1) | 295 (31.3) | <0.001 | 1,097 (22.6) | 0.475 | 5,790 (33.7) | <0.001 | 1,650 (35.6) | <0.001 |
| 45–49, n (%) | 1,386 (10.0) | 552 (6.9) | 310 (32.9) | <0.001 | 524 (10.8) | <0.001 | 7,034 (40.9) | <0.001 | 1,994 (43.1) | <0.001 |
| Geographic region, n (%) | ||||||||||
| Northeast | 2,448 (17.7) | 1,389 (17.3) | 225 (23.9) | <0.001 | 834 (17.2) | 0.873 | 2,822 (16.4) | 0.011 | 742 (16.0) | 0.022 |
| North Central | 2,221 (16.0) | 1,094 (13.6) | 189 (20.1) | <0.001 | 928 (19.2) | <0.001 | 4,070 (23.7) | <0.001 | 879 (19.0) | <0.001 |
| South | 6,748 (48.9) | 4,176 (52.1) | 345 (36.7) | <0.001 | 2,227 (46.2) | <0.001 | 6,706 (39.0) | <0.001 | 2,258 (48.8) | 0.333 |
| West | 2,176 (15.8) | 1,246 (15.5) | 173 (18.4) | 0.024 | 757 (15.6) | 0.898 | 3,241 (18.8) | <0.001 | 637 (13.8) | <0.001 |
| Other/unknown | 221 (1.6) | 113 (1.4) | 9 (1.0) | 0.257 | 99 (2.0) | 0.006 | 359 (2.1) | 0.001 | 113 (2.4) | 0.002 |
| Days from earliest diagnosis to first intervention, n (%) | ||||||||||
| ≤90 | 5,879 (42.6) | 2,995 (37.4) | 658 (69.9) | <0.001 | 2,226 (45.9) | <0.001 | 11,826 (68.8) | <0.001 | 1,462 (31.6) | <0.001 |
| >90 | 7,925 (57.4) | 5,023 (62.6) | 283 (30.1) | <0.001 | 2,619 (54.1) | <0.001 | 5,372 (31.2) | <0.001 | 3,167 (68.4) | <0.001 |
| Year of first UF-related procedure, n (%) | ||||||||||
| 2009 | 2,282 (16.5) | 1,534 (19.1) | 156 (16.6) | 0.058 | 592 (12.2) | <0.001 | 2,794 (16.2) | 0.253 | 909 (19.6) | <0.001 |
| 2010 | 2,597 (18.8) | 1,620 (20.2) | 171 (18.2) | 0.140 | 806 (16.6) | <0.001 | 3,204 (18.6) | 0.398 | 963 (20.8) | 0.007 |
| 2011 | 3,225 (23.4) | 1,847 (23.0) | 215 (22.8) | 0.897 | 1,163 (24.0) | 0.209 | 4,103 (23.9) | 0.249 | 1,072 (23.2) | 0.837 |
| 2012 | 2,859 (20.7) | 1,551 (19.3) | 207 (22.0) | 0.052 | 1,101 (22.7) | <0.001 | 3,641 (21.2) | 0.266 | 847 (18.3) | <0.001 |
| 2013 | 2,841 (20.6) | 1,466 (18.3) | 192 (20.4) | 0.113 | 1,183 (24.4) | <0.001 | 3,456 (20.1) | 0.639 | 838 (18.1) | 0.001 |
| Days from first intervention to loss of follow-up, mean (SD) [median] | 960.7 (462.4) [854] | 989.0 (477.5) [888] | 982.3 (463.5) [891] | 0.944 | 909.8 (431.6) [796] | <0.001 | 977.3 (463.0) [880] | <0.001 | 1,016.5 (488.3) [919] | <0.001 |
| Comorbidities, n (%) | ||||||||||
| Abdominal pain | 3,333 (24.1) | 1,949 (24.3) | 153 (16.3) | <0.001 | 1,231 (25.4) | 0.161 | 2,654 (15.4) | <0.001 | 982 (21.2) | <0.001 |
| Anemia | 3,250 (23.5) | 2,062 (25.7) | 294 (31.2) | <0.001 | 894 (18.5) | <0.001 | 4,495 (26.1) | <0.001 | 1,593 (34.4) | <0.001 |
| Endometrial polyp/other disorders of the uterus | 2,339 (16.9) | 1,291 (16.1) | 230 (24.4) | <0.001 | 818 (16.9) | 0.246 | 3,916 (22.8) | <0.001 | 1,018 (22.0) | <0.001 |
| Heavy menstrual bleeding | 4,789 (34.7) | 2,625 (32.7) | 517 (54.9) | <0.001 | 1,647 (34.0) | 0.143 | 11,942 (69.4) | <0.001 | 2,448 (52.9) | <0.001 |
| Infertility | 2,081 (15.1) | 1,118 (13.9) | 50 (5.3) | <0.001 | 913 (18.8) | <0.001 | 924 (5.4) | <0.001 | 44 (1.0) | <0.001 |
| Obesity | 785 (5.7) | 474 (5.9) | 60 (6.4) | 0.569 | 251 (5.2) | 0.082 | 1,256 (7.3) | <0.001 | 310 (6.7) | 0.032 |
| Other disorders of menstruation or abnormal bleeding | 5,172 (37.5) | 2,863 (35.7) | 511 (54.3) | <0.001 | 1,798 (37.1) | 0.109 | 10,689 (62.2) | <0.001 | 1,733 (37.4) | 0.821 |
| Ovarian cyst | 2,356 (17.1) | 1,201 (15.0) | 121 (12.9) | 0.082 | 1,034 (21.6) | <0.001 | 2,423 (14.1) | <0.001 | 721 (15.6) | 0.062 |
| Pelvic inflammatory disease | 2,633 (19.1) | 1,494 (18.6) | 159 (16.9) | 0.194 | 980 (20.2) | 0.026 | 2,287 (13.3) | <0.001 | 793 (17.1) | 0.008 |
| Pelvic pain | 5,421 (39.3) | 2,888 (36.0) | 252 (26.8) | <0.001 | 2,281 (47.1) | <0.001 | 4,648 (27.0) | <0.001 | 1,514 (32.7) | <0.001 |
| Urinary problems | 680 (4.9) | 389 (4.9) | 36 (3.8) | 0.161 | 255 (5.3) | 0.300 | 484 (2.8) | <0.001 | 309 (6.7) | <0.001 |
| CCI, mean (SD) | 0.22 (0.66) | 0.22 (0.66) | 0.24 (0.71) | 0.424 | 0.22 (0.66) | 0.254 | 0.28 (0.76) | <0.001 | 0.27 (0.71) | <0.001 |
Source: Truven MarketScan Commercial Claims and Encounters data for 2008–2014.
Demographics assessed at the time of initial intervention. Comorbidities evaluated in the 12 months before the first UF-related procedure.
a
Wilcoxon rank-sum tests and chi-squared tests were used to compare continuous and categorical variables, respectively.
b
All comparisons are relative to the myomectomy cohort.
CCI, Charlson Comorbidity Index; EA, endometrial ablation; UAE, uterine artery embolization; UF, uterine fibroids.