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. 2018 Oct 12;27(20):1412–1425. doi: 10.1089/scd.2018.0071

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Copyright 2018, Mary Ann Liebert, Inc., publishers

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FIG. 4. — Micro-CT showed abnormal and more bone filled the whole medullary cavities (days 5, 10, and 21 after birth). (A) Deleted Ihh in mesenchyme has a short and wide limb as well as no digital joint formation. (B) The medullary cavities were well developed in the WT mice (top) while they were filled completely with bone (bottom). (C) A similar result was found at P21. (C–a, b) Ihh +/+ mice tibia micro-CT results; (C–c) Ihh +/+ mice 3D reconstruction of the tibia trabecular bone. (C–d, e, f) Ihh +/+ mice foot micro-CT results; (C–g, h) Ihh d/d mice tibia micro-CT results; (C–i) Ihh d/d mice 3D reconstruction of the tibia trabecular bone. (C–j, k, l) Ihh d/d mice foot micro-CT results. (D) The more trabecular bone was found in the deleted Ihh mice compared with the littermate control at P21. (E) Bone histomorphometric analyses. **P < 0.01; n = 6. (F, G) X-ray and micro-CT further confirmed no digital joint formation at P42 in mutant mice. BV/TV, bone volume per total volume; micro-CT, microcomputed tomography; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness.

FIG. 4. — Micro-CT showed abnormal and more bone filled the whole medullary cavities (days 5, 10, and 21 after birth). (A) Deleted Ihh in mesenchyme has a short and wide limb as well as no digital joint formation. (B) The medullary cavities were well developed in the WT mice (top) while they were filled completely with bone (bottom). (C) A similar result was found at P21. (C–a, b) Ihh +/+ mice tibia micro-CT results; (C–c) Ihh +/+ mice 3D reconstruction of the tibia trabecular bone. (C–d, e, f) Ihh +/+ mice foot micro-CT results; (C–g, h) Ihh d/d mice tibia micro-CT results; (C–i) Ihh d/d mice 3D reconstruction of the tibia trabecular bone. (C–j, k, l) Ihh d/d mice foot micro-CT results. (D) The more trabecular bone was found in the deleted Ihh mice compared with the littermate control at P21. (E) Bone histomorphometric analyses. **P < 0.01; n = 6. (F, G) X-ray and micro-CT further confirmed no digital joint formation at P42 in mutant mice. BV/TV, bone volume per total volume; micro-CT, microcomputed tomography; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness.