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. 2018 Aug 23;7(11):e1461303. doi: 10.1080/2162402X.2018.1461303

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Figure 5. — Blockade of STAT3/NF-κB/Notch1 signaling inhibited NSCLC stemness promoted by IL-17░A. (A) After the treatment with STAT3░or NF-κB or Notch1 inhibitor, the sphere forming of A549 and H460 cells induce by rhIL-17░A was blocked. One representative photomicrograph is shown. The results from A549 (B) and H460 (C) cells were shown as histogram. (D) The expression of Oct4 in A549 and H460 cells treated with or without rhIL-17░A and these molecular inhibitors were assessed by western blotting. The apoptosis of A549 (E) and H460 (F) cells treated with or without rhIL-17░A and these molecular inhibitors were assessed by transwell assay. * indicates P < 0.05. Scale bar represents 100 μm.