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Pathway for EBV reactivation-induced Ig production. B cells newly infected by EBV become latency 3 and express LMP1. LMP1 activates host cells (polyclonal B cell activation). LMP1 stimulates AID expression through NF-κB, which enables host cells to class-switch Ig. EBV reactivation induces plasma cell differentiation and Ig production. AID, activation-induced cytidine deaminase; EBV, Epstein–Barr virus; Ig, immunoglobulin; NF-κB, nuclear factor-kappa B.
