Table 4.

Summary of mean organ weight (g) and organ weight relative to body weight (%) for male and female rats in the 2 weeks oral repeated dose finding study.

		Control (G1)	500 mg/kg/day (G2)	1000 mg/kg/day (G3)	2000 mg/kg/day (G4)
Males
Body	g	313.21 ± 25.82	317.80 ± 17.01	341 ± 14.96	318 ± 20.10
Testis (Lt.)	g	1.40 ± 0.09	1.46 ± 0.15	1.48 ± 0.06	1.51 ± 0.06
	%	0.45 ± 0.05	0.46 ± 0.03	0.43 ± 0.0	0.47 ± 0.03
Testis (Rt.)	g	1.41 ± 0.06	1.49 ± 0.13	1.49 ± 0.10	1.53 ± 0.06
	%	0.45 ± 0.04	0.46 ± 0.02	0.43 ± 0.04	0.48 ± 0.02
Prostate	g	0.52 ± 0.20	0.42 ± 0.06	0.44 ± 0.07	0.51 ± 0.14
	%	0.16 ± 0.07	0.13 ± 0.001	0.13 ± 0.02	0.16 ± 0.04
Spleen	g	0.76 ± 0.09	0.75 ± 0.07	0.77 ± 0.05	0.72 ± 0.08
	%	0.24 ± 0.04	0.23 ± 0.02	0.22 ± 0.02	0.22 ± 0.03
Liver	g	11.01 ± 2.06	11.72 ± 1.50	12.54 ± 0.49	11.69 ± 1.26
	%	3.49 ± 0.40	3.68 ± 0.33	3.67 ± 0.23	3.66 ± 0.19
Adrenal (Lt.)	g	0.026 ± 0.004	0.023 ± 0.006	0.025 ± 0.002	0.023 ± 0.005
	%	0.008 ± 0.001	0.007 ± 0.001	0.007 ± 0.002	0.007 ± 0.001
Adrenal (Rt.)	g	0.024 ± 0.003	0.022 ± 0.002	0.024 ± 0.002	0.022 ± 0.005
	%	0.007 ± 0.001	0.007 ± 0.000	0.007 ± 0.000	0.007 ± 0.002
Kidney (Lt.)	g	1.27 ± 0.12	1.27 ± 0.09	1.33 ± 0.04	1.18 ± 0.14
	%	0.40 ± 0.03	0.40 ± 0.02	0.39 ± 0.01	0.37 ± 0.07
Kidney (Rt.)	g	1.33 ± 0.09	1.33 ± 0.10	1.41 ± 0.05	1.18 ± 0.10ª
	%	0.42 ± 0.03	0.41 ± 0.0)	0.41 ± 0.01	0.37 ± 0.02a
Heart	g	1.20 ± 0.15	1.21 ± 0.15	1.98 ± 0.10	1.26 ± 0.07
	%	0.38 ± 0.05	0.38 ± 0.03	0.35 ± 0.03	0.40 ± 0.05
Lung	g	1.88 ± 0.44	1.65 ± 0.24	1.77 ± 0.31	1.84 ± 0.32
	%	0.60 ± 0.13	0.52 ± 0.08	0.52 ± 0.05	0.57 ± 0.08
Brain	g	2.03 ± 0.08	2.06 ± 0.05	1.98 ± 0.10	1.92 ± 0.06
	%	0.65 ± 0.04	0.65 ± 0.03	0.58 ± 0.05b	0.60 ± 0.0
Thymus	g	0.54 ± 0.14	0.65 ± 0.14	0.61 ± 0.10	0.55 ± 0.13
	%	0.17 ± 0.03	0.20 ± 0.03	0.17 ± 0.03	0.17 ± 0.03
		Control	500 mg/kg/day	1000 mg/kg/day	2000 mg/kg/day
Females
Body	g	204.33 ± 25.74	204 ± 20.20	203.24 ± 7.29	199.28 ± 3.91
Ovary (Lt.)	g	0.03 ± 0.006	0.04 ± 0.009	0.033 ± 0.008	0.030 ± 0.006
	%	0.014 ± 0.003	0.019 ± 0.004	0.016 ± 0.004	0.015 ± 0.003
Ovary (Rt.)	g	0.04 ± 0.009	0.04 ± 0.018	0.030 ± 0.004	0.033 ± 0.004
	%	0.014 ± 0.004	0.02 ± 0.008	0.015 ± 0.002	0.016 ± 0.002
Uterus	g	0.36 ± 0.04	0.58 ± 0.20	0.33 ± 0.03c	0.42 ± 0.04
	%	0.18 ± 0.01	0.29 ± 0.11	0.16 ± 0.01c	0.21 ± 0.02
Spleen	g	0.50 ± 0.09	0.52 ± 0.06	0.52 ± 0.09	0.45 ± 0.12
	%	0.24 ± 0.01	0.25 ± 0.009	0.25 ± 0.04	0.22 ± 0.05
Liver	g	7.34 ± 1.37	7.42 ± 1.00	7.05 ± 0.59	7.52 ± 0.11
	%	3.57 ± 0.24	3.61 ± 0.16	3.48 ± 0.21	3.77 ± 0.08
Adrenal (Lt.)	g	0.02 ± 0.006	0.03 ± 0.004	0.029 ± 0.008	0.028 ± 0.005
	%	0.014 ± 0.002	0.014 ± 0.001	0.014 ± 0.004	0.014 ± 0.002
Adrenal (Rt.)	g	0.02 ± 0.005	0.028 ± 0.003	0.028 ± 0.005	0.024 ± 0.006
	%	0.014 ± 0.001	0.013 ± 0.000	0.014 ± 0.003	0.012 ± 0.003
Kidney (Lt.)	g	0.82 ± 0.11	0.82 ± 0.12	0.83 ± 0.09	0.82 ± 0.03
	%	0.40 ± 0.02	0.40 ± 0.04	0.41 ± 0.04	0.41 ± 0.01
Kidney (Rt.)	g	0.82 ± 0.09	0.82 ± 0.10	0.87 ± 0.10	0.83 ± 0.08
	%	0.40 ± 0.03	0.40 ± 0.03	0.43 ± 0.02	0.41 ± 0.03
Heart	g	0.76 ± 0.08	0.84 ± 0.09	0.85 ± 0.04	0.76 ± 0.03
	%	0.37 ± 0.02	0.41 ± 0.02d	0.42 ± 0.02c, d	0.38 ± 0.01
Lung	g	1.27 ± 0.12	1.33 ± 0.34	1.18 ± 0.07	1.48 ± 0.09
	%	0.63 ± 0.09	0.64 ± 0.11	0.58 ± 0.03	0.74 ± 0.06
Brain	g	1.80 ± 0.08	1.77 ± 0.09	1.79 ± 0.09	1.80 ± 0.07
	%	0.89 ± 0.09	0.87 ± 0.07	0.88 ± 0.04	0.90 ± 0.02
Thymus	g	0.54 ± 0.16	0.57 ± 0.09	0.60 ± 0.14	0.47 ± 0.072
	%	0.26 ± 0.06	0.28 ± 0.02	0.30 ± 0.07	0.23 ± 0.03

abbreviationd: Rt = Right, Lt = Left.

Values are means ± SD.

^aSignificant difference compared with control, 500, 1000 mg/kg group value, p < 0.05.

^bSignificant difference compared with control, 500 mg/kg group value, p < 0.05.

^cSignificant difference compared with 2000 mg/kg group value, p < 0.05.

^dSignificant difference compared with control group value, p < 0.05.