Table 5.
Summary of Body weight (BW) and Fold weight gain (FWG) data in rats’ subchronic 13-week oral toxicity study.
| Weeks | Control(G1) | 250 mg/kg/day(G2) | 500 mg/kg/day (G3) | 1000 mg/kg/day (G4) | |
|---|---|---|---|---|---|
| Males | |||||
| 0 | BW | 202.46 ± 9.45 | 201.84 ± 10.77 | 202.42 ± 9.11 | 202.77 ± 4.50 |
| 1 | BW | 248.70 ± 13.66 | 235.57 ± 16.43 | 245.00 ± 9.61 | 249.68 ± 6.39 |
| 2 | BW | 312.45 ± 18.15 | 299.83 ± 20.12 | 303.30 ± 12.59 | 312.65 ± 14.14 |
| 3 | BW | 372.53 ± 26.85 | 347.42 ± 26.67 | 353.10 ± 27.26 | 372.04 ± 20.08 |
| 4 | BW | 422.97 ± 34.18 | 388.29 ± 31.67 | 401.36 ± 32.91 | 420.33 ± 26.58 |
| 5 | BW | 468.66 ± 40.56 | 422.46 ± 36.92a | 437.80 ± 36.20 | 461.07 ± 30.97 |
| 6 | BW | 503.00 ± 42.97 | 458.75 ± 38.40 | 466.91 ± 42.72 | 493.94 ± 34.92 |
| 7 | BW | 525.85 ± 40.36 | 487.86 ± 44.87 | 494.97 ± 43.86 | 521.89 ± 35.98 |
| 8 | BW | 562.85 ± 48.95 | 509.94 ± 46.15a | 519.03 ± 46.44a | 551.59 ± 38.98 |
| 9 | BW | 581.21 ± 53.69 | 532.69 ± 49.30 | 539.71 ± 49.38 | 575.74 ± 45.72 |
| 10 | BW | 603.21 ± 54.32 | 543.32 ± 51.94a | 559.88 ± 51.39 | 596.04 ± 49.50 |
| 11 | BW | 625.75 ± 55.99 | 567.04 ± 51.94a | 577.27 ± 54.26 | 616.77 ± 50.35 |
| 12 | BW | 644.76 ± 61.49 | 583.34 ± 54.09a | 591.18 ± 53.33 | 639.42 ± 56.59 |
| 13 | BW | 654.38 ± 66.20 | 594.59 ± 54.67 | 609.99 ± 56.82 | 650.64 ± 61.70 |
| necropsy | BW | 640.31 ± 62.52 | 582.92 ± 53.51 | 595.07 ± 56.88 | 631.75 ± 63.42 |
| FWG | 3.16 | 2.89 | 2.94 | 3.12 | |
| Females | |||||
| 0 | BW | 155.33 ± 9.10 | 156.95 ± 5.62 | 155.38 ± 7.35 | 156.07 ± 7.46 |
| 1 | BW | 180.64 ± 12.00 | 177.75 ± 12.02 | 177.19 ± 8.40 | 173.43 ± 10.64 |
| 2 | BW | 207.73 ± 14.35 | 202.38 ± 15.52 | 195.78 ± 9.80 | 192.05 ± 14.91 |
| 3 | BW | 226.91 ± 19.24 | 219.40 ± 21.69 | 223.27 ± 14.99 | 210.75 ± 16.43 |
| 4 | BW | 251.02 ± 23.11 | 239.00 ± 25.26 | 245.71 ± 16.03 | 225.50 ± 16.09a |
| 5 | BW | 269.60 ± 23.02 | 255.92 ± 30.13 | 260.43 ± 13.91 | 241.28 ± 20.91 |
| 6 | BW | 283.77 ± 21.33 | 267.19 ± 27.14 | 271.16 ± 13.64 | 253.77 ± 20.9a |
| 7 | BW | 291.93 ± 22.95 | 274.01 ± 25.13 | 284.89 ± 14.66 | 261.00 ± 23.81a |
| 8 | BW | 305.96 ± 28.27 | 281.20 ± 29.85a | 291.56 ± 15.55 | 269.96 ± 20.30a |
| 9 | BW | 314.89 ± 26.89 | 287.51 ± 29.49b | 302.35 ± 15.81 | 277.51 ± 24.02b |
| 10 | BW | 321.04 ± 26.41 | 294.37 ± 29.21a | 305.54 ± 14.37 | 284.36 ± 24.20a |
| 11 | BW | 328.95 ± 27.72 | 298.70 ± 35.45a | 312.87 ± 13.69 | 288.90 ± 24.92a |
| 12 | BW | 334.37 ± 31.63 | 302.94 ± 35.32b | 321.13 ± 13.57 | 288.67 ± 22.55b |
| 13 | BW | 338.62 ± 28.76 | 308.19 ± 35.50a | 324.79 ± 13.44 | 297.94 ± 25.91a |
| necropsy | 325.21 ± 25.90 | 295.89 ± 34.91b | 313.71 ± 14.59 | 286.54 ± 24.63b | |
| FWG | 2.09 | 1.89 | 2.02 | 1.84 | |
Values are Mean ± SD.
a
Significant difference compare with control group value, p < 0.05.
b
Significant difference compare with control value, p < 0.01.