Table 8.

Summary of mean organ weight (g) and organ weight relative to body weight (%) for male in the 13 weeks oral toxicity study.

		Control (G1)	250 mg/kg/day (G2)	500 mg/kg/day (G3)	1000 mg/kg/day (G4)
Males
Body Weight	g	640.31 ± 62.52	582.92 ± 53.51	595.07 ± 56.88	631.42 ± 63.42
Testis (Lt.)	g	1.79 ± 0.13	1.69 ± 0.11	1.59 ± 0.10b	1.76 ± 0.07
	%	0.28 ± 0.03	0.29 ± 0.03	0.27 ± 0.03	0.28 ± 0.02
Testis (Rt.)	g	1.78 ± 0.12	1.69 ± 0.13	1.60 ± 0.10b	1.77 ± 0.09
	%	0.28 ± 0.03	0.29 ± 0.02	0.27 ± 0.03	0.28 ± 0.03
Prostate	g	0.87 ± 0.17	0.93 ± 00.12	0.86 ± 0.14	0.82 ± 0.22
	%	0.13 ± 0.02	0.16 ± 0.02	0.14 ± 0.02	0.13 ± 0.03
Spleen	g	0.81 ± 0.10	0.81 ± 0.11	0.87 ± 0.12	0.86 ± 0.11
	%	0.12 ± 0.01	0.13 ± 0.01	0.14 ± 0.01	0.13 ± 0.02
Liver	g	17.90 ± 1.84	15.44 ± 1.84	16.54 ± 2.11	17.99 ± 1.72
	%	2.79 ± 0.13	2.64 ± 0.17	2.77 ± 0.16	2.85 ± 0.15
Adrenal (Lt.)	g	0.027 ± 0.005	0.027 ± 0.003	0.029 ± 0.004	0.027 ± 0.002
	%	0.004 ± 0.001	0.004 ± 0.0006	0.005 ± 0.0008	0.004 ± 0.0006
Adrenal (Rt.)	g	0.025 ± 0.005	0.024 ± 0.004	0.029 ± 0.005	0.026 ± 0.003
	%	0.004 ± 0.001	0.004 ± 0.0008	0.005 ± 0.0008	0.004 ± 0.0006
Kidney (Lt.)	g	1.60 ± 0.14	1.50 ± 0.20	1.63 ± 0.17	1.60 ± 0.11
	%	0.25 ± 0.01	0.25 ± 0.02	0.27 ± 0.02	0.25 ± 0.02
Kidney (Rt.)	g	1.63 ± 0.14	1.56 ± 00.24	1.63 ± 0.13	1.66 ± 0.14
	%	0.25 ± 0.01	0.26 ± 0.03	0.27 ± 0.01	0.26 ± 0.03
Heart	g	1.62 ± 0.15	1.52 ± 0.17	1.55 ± 0.10	1.69 ± 0.11
	%	0.25 ± 0.01	0.26 ± 0.01	0.26 ± 0.01	0.26 ± 0.02
Lung	g	1.74 ± 0.20	1.74 ± 0.37	1.77 ± 0.20	1.88 ± 0.29
	%	0.27 ± 0.02	0.29 ± 0.05	0.29 ± 0.03	0.29 ± 0.03
Brain	g	2.13 ± 0.07	2.17 ± 0.09	2.17 ± 0.10	2.14 ± 0.09
	%	0.33 ± 0.02	0.37 ± 0.03	0.36 ± 0.03a	0.34 ± 0.03
Pituitary	g	0.011 ± 0.002	0.010 ± 0.002	0.009 ± 0.002	0.009 ± 0.001
	%	0.001 ± 0.0004	0.001 ± 0.0004	0.001 ± 0.0004	0.001 ± 0.0003
Thymus	g	0.25 ± 0.09	0.30 ± 0.09	0.27 ± 0.07	0.33 ± 0.10
	%	0.04 ± 0.01	0.05 ± 0.01	0.04 ± 0.01	0.05 ± 0.01

Values are Mean ± SD.

^aSignificant difference compared with control, 500, 1000 mg/kg group value, p < 0.05.

^bSignificant difference compared with control, 500 mg/kg group value, p < 0.05.