Table 9.

Summary of mean organ weight (g) and organ weight relative to body weight (%) for female in the 13 weeks oral toxicity study.

		Control (G1)	250 mg/kg/day (G2)	500 mg/kg/day (G3)	1000 mg/kg/day (G4)
Females
Body Weight	g	325.21 ± 25.90	295.86 ± 34.91b	313.71 ± 14.59	286.54 ± 24.63b
Ovary (Lt.)	g	0.04 ± 0.009	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.009
	%	0.012 ± 0.003	0.014 ± 0.005	0.014 ± 0.003	0.016 ± 0.003
Ovary (Rt.)	g	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.007
	%	0.012 ± 0.003	0.015 ± 0.003	0.015 ± 0.004	0.015 ± 0.002
Uterus	g	0.68 ± 0.26	0.74 ± 0.38	0.67 ± 0.33	0.71 ± 0.19
	%	0.21 ± 0.08	0.26 ± 0.16	0.21 ± 0.11	0.25 ± 0.07
Spleen	g	0.56 ± 0.06	0.57 ± 0.15	0.56 ± 0.07	0.56 ± 0.06
	%	0.17 ± 0.02	0.19 ± 0.07	0.18 ± 0.02	0.19 ± 0.01
Liver	g	8.67 ± 1.22	8.08 ± 0.92	8.49 ± 0.54	7.98 ± 1.01
	%	2.66 ± 0.31	2.75 ± 0.39	2.70 ± 0.10	2.77 ± 0.15
Adrenal (Lt.)	g	0.03 ± 0.004	0.03 ± 0.01	0.03 ± 0.005	0.03 ± 0.004
	%	0.010 ± 0.001	0.012 ± 0.003	0.010 ± 0.001	0.011 ± 0.001
Adrenal (Rt.)	g	0.03 ± 0.005	0.03 ± 0.007	0.03 ± 0.004	0.03 ± 0.004
	%	0.009 ± 0.002	0.012 ± 0.002	0.010 ± 0.001	0.010 ± 0.001
Kidney (Lt.)	g	0.93 ± 0.09	0.92 ± 0.13	0.92 ± 0.07	0.91 ± 0.12
	%	0.28 ± 0.02	0.31 ± 0.05	0.29 ± 0.02	0.32 ± 0.02
Kidney (Rt.)	g	0.97 ± 0.09	0.93 ± 0.14	0.96 ± 0.07	0.95 ± 0.16
	%	0.29 ± 0.02	0.31 ± 0.05	0.30 ± 0.02	0.33 ± 0.04
Heart	g	1.02 ± 0.09	0.92 ± 0.11a	1.01 ± 0.07	0.94 ± 0.07
	%	0.31 ± 0.02	0.31 ± 0.03	0.32 ± 0.01	0.33 ± 0.01
Lung	g	1.31 ± 0.13	1.27 ± 0.15	1.29 ± 0.16	1.21 ± 0.10
	%	0.40 ± 0.02	0.43 ± 0.06	0.41 ± 0.06	0.42 ± 0.03
Brain	g	1.95 ± 0.06	1.94 ± 0.10	1.96 ± 0.07	1.98 ± 0.08
	%	0.60 ± 0.05	0.66 ± 0.09	0.62 ± 0.04	0.69 ± 0.06a
Pituitary	g	0.016 ± 0.006	0.014 ± 0.004	0.015 ± 0.003	0.014 ± 0.003
	%	0.0050 ± 0.002	0.0049 ± 0.001	0.0048 ± 0.001	0.0051 ± 0.001
Thymus	g	0.23 ± 0.03	0.25 ± 0.04	0.26 ± 0.05	0.25 ± 0.07
	%	0.07 ± 0.006	0.08 ± 0.010	0.08 ± 0.019	0.08 ± 0.022

Values are Mean ± SD.

^aSignificant difference compared with 2000 mg/kg group value, p < 0.05.

^bSignificant difference compared with control group value, p < 0.05.