Table 3.
Summarized results of meta-analysis based on R.
| Subgroup analysis | SEN(95%CI) | SPE(95%CI) | DOR(95%CI) | PLR(95%CI) | NLR(95%CI) | AUC |
|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | 0.87(0.838-0.897) | 0.829(0.794-0.86) | 23.085(20.575-25.901) | 4.533(4.239-4.847) | 0.176(0.166-0.186) | 0.915 |
| LncRNA profiling | ||||||
| Single lncRNA | 0.862(0.825-0.892) | 0.805(0.76-0.844) | 20.027(17.638-22.740) | 4.129(3.839-4.441) | 0.191(0.179-0.204) | 0.902 |
| Multiple lncRNAs | 0.898(0.82-0.944) | 0.886(0.845-0.916) | 43.220(32.833-56.893) | 6.736(5.627-8.064) | 0.127(0.115-0.140) | 0.940 |
| Sample source | ||||||
| Plasma | 0.884(0.827-0.924) | 0.803(0.732-0.859) | 14.132(11.992-16.654) | 3.449(3.118-3.815) | 0.203(0.187-0.221) | 0.911 |
| Serum | 0.869(0.824-0.904) | 0.856(0.829-0.879) | 35.971(30.089-43.002) | 6.057(5.504-6.666) | 0.160(0.147-0.173) | 0.916 |
| Tissue | 0.892(0.862-0.916) | 0.784(0.421-0.948) | 52.000(35.881-75.359) | 6.473(5.075-8.256) | 0.123(0.099-0.153) | 0.887 |
| Sample size | ||||||
| Small sample(<200) | 0.832(0.792-0.866) | 0.829(0.775-0.883) | 18.825(15.341-23.101) | 4.065(3.652-4.524) | 0.211(0.189-0.236) | 0.894 |
| Large sample(⩾200) | 0.903(0.856-0.936) | 0.83(0.779-0.871) | 25.207(21.927-28.979) | 4.736(4.343-5.164) | 0.162(0.152-0.173) | 0.927 |
| Ethnicity | ||||||
| Asian | 0.873(0.837-0.902) | 0.836(0.796-0.869) | 23.549(20.864-26.579) | 4.575(4.256-4.917) | 0.175(0.166-0.185) | 0.919 |
| African | 0.868(0.787-0.922) | 0.797(0.73-0.851) | 21.042(14.488-30.561) | 4.293(3.538-5.211) | 0.178(0.124-0.255) | 0.875 |
SEN, sensitivity; SPE, specificity; DOR, diagnostic odds ratio; PLR, positive likelihood ratio; NLR, negative likelihood ratio; AUC, area under the curve.