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. 2018 Oct 14;4:542–555. doi: 10.1016/j.trci.2018.09.001

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 1 — The cognitive decline in set 1 patients by different aHTN treatment groups was analyzed using a mixed-effect regression model. Combination of diuretics, calcium channel blockers, and renin-angiotensin-aldosterone system inhibitors (diuretics + CCB + RAAS) was associated with the slowest rate of cognitive decline among all groups tested (Δβ = +1.46, P < .0001). This effect was most prominent in the first 3 years of aHTN treatment. Abbreviations: aHTN, antihypertensive; MMSE, Mini-Mental State Examination.