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. 2018 Oct 14;4:542–555. doi: 10.1016/j.trci.2018.09.001

Fig. 3.

Fig. 3

Overlapping protein targets for Alzheimer's disease (red) and hypertension (cyan). Each node represents a protein target name that is associated with the disease(s) linked to it by a straight line. Targets highlighted in solid line circles indicate the drug classes that are shown to have potential synergetic effects by our data-mining analysis in clinical and molecular levels. Abbreviations: ACE, angiotensin-converting enzyme; AGTR1, angiotensin receptor 1; CACNA1A, calcium voltage-gated channel auxiliary subunit alpha1 A; CACNA2D1, calcium voltage-gated channel auxiliary subunit alpha2delta1; CACNA2D4, calcium voltage-gated channel auxiliary subunit alpha2delta4; CACNB2, calcium voltage-gated channel auxiliary subunit beta1; PPARγ, peroxisome proliferator–activated receptor gamma.