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Time to achieve RFMB in patients with chronic noncancer pain and OIC receiving methadone was reduced by methylnaltrexone treatment.
Notes: Patients were censored at 24 hours or the time of the second dose. P=0.9 methylnaltrexone 150 mg vs placebo. P=0.02 methylnaltrexone 300 mg vs placebo. P=0.07 methylnaltrexone 450 mg vs placebo.
Abbreviations: OIC, opioid-induced constipation; RFBM, rescue-free bowel movement.
