Fig. 4.
Aclerastide treatment results in upregulation of active MMP-9. Quantitative analysis of wound tissues using the affinity resin coupled with proteomics. Mean ± S.D., n = 3 mice per group per time point, *P < 0.05 by Student’s t two-tailed test. A. Active MMP-9 is upregulated in aclerastide-treated wounds, resulting in 2.7- and 2.5-fold increases on days 1 and 2, respectively. B. No statistically significant differences were observed in the levels of active MMP-8 in aclerastide-treated wounds compared to vehicle-treated ones (P = 0.08).