Table 2.
Clinical findings of patients with svPPA who underwent [18F]THK-5351 PET imaging
| Reference | Sex/age (years) |
Duration (years) |
MMSE (/30) |
Clinical presentation | Atrophy- predominant | MRI findings | THK-5351 retention |
|---|---|---|---|---|---|---|---|
| Takaya M et al., 2017 [7] | F/69 | 5 | 12 | Comprehension difficulty, surface dyslexia | L > R | Bilateral anterior temporal lobe atrophy | Bilateral anterior temporal regions |
| Lee H et al., 2017 [8] | F/79 | 4 | 8 (average of 5 cases) |
Comprehension difficulty, compulsive behavior | L > R | Bilateral anterior temporal lobe atrophy | Bilateral anterolateral temporal regions |
| F/76 | 3 | 8 (average of 5 cases) |
Anomia, comprehension difficulty, inappropriate social behavior | R > L | Bilateral anterior temporal lobe atrophy | Bilateral anterolateral temporal regions | |
| M/50 | 10 | 8 (average of 5 cases) |
Anomia, comprehension difficulty, prosopagnosia, behavioral changes | L > R | Bilateral anterior temporal lobe atrophy | Bilateral anterolateral temporal regions | |
| F/60 | 1 | 8 (average of 5 cases) |
Comprehension difficulty, prosopagnosia, behavioral changes | L > R | Bilateral anterior temporal lobe atrophy | Bilateral anterolateral temporal regions | |
| M/66 | 2 | 8 (average of 5 cases) |
Anomia, comprehension difficulty | L > R | Bilateral anterior temporal lobe atrophy | Bilateral anterolateral temporal regions | |
| Jang YK et al., 2017 [9] | M/68 | NA | 20 | Decreased understanding ability, confusion about names of objects | R > L | Bilateral anterior temporal lobe atrophy | Bilateral anterior and inferior temporal regions |
F female, L left, M male, MRI magnetic resonance imaging, NA not available, R right, svPPA semantic variant primary progressive aphasia, THK-5351: [18F]THK-5351