Table 1.
Association of baseline covariates with T2D incidence: univariate effects and variable by interaction with SVR
| Variable | Response | Sample (n = 5127) | Hazard ratio | P- value | P- value for interaction with SVR |
|---|---|---|---|---|---|
| Treatment status | Failure | 1379 (27%) | Reference | .0003 | NA |
| SVR | 3748 (73%) | 0.706 | |||
| Sex | Female | 2043 (40%) | Reference | .1931 | .041 |
| Male | 3084 (60%) | 1.131 | |||
| Age, y | <40 | 624 (12%) | Reference | .0001 | .289 |
| 40 < 50 | 1242 (24%) | 2.121 | |||
| 50 < 60 | 1886 (37%) | 2.36 | |||
| ≥60 | 1375 (27%) | 2.341 | |||
| Race | White | 3714 (72%) | Reference | <.001 | .480 |
| African American |
881 (17%) | 1.92 | |||
| ASINPI | 297 (6%) | 1.76 | |||
| Unknown | 235 (5%) | 1.131 | |||
| Hispanic/Latino | No | 4116 (80%) | Reference | .0062 | .257 |
| Yes | 213 (4%) | 1.87 | |||
| Unknown | 798 (16%) | 1.121 | |||
| Household income, US $ | <15K | 106 (2%) | Reference | .409 | .022 |
| 15 < 30K | 785 (15%) | 1.182 | |||
| 30 < 50K | 2154 (42%) | 0.949 | |||
| 50 < 75K | 1327 (26%) | 0.913 | |||
| ≥75K | 465 (9%) | 0.815 | |||
| Missing | 290 (6%) | 1.083 | |||
| BMI, kg/m2 | <25 | 939 (18%) | Reference | <.0001 | .127 |
| 25– 30 | 1272 (25%) | 1.797 | |||
| ≥30 | 1405 (27%) | 3.814 | |||
| Missing | 1511 (29%) | 3.018 | |||
| HCV genotype | 1 | 3201 (62%) | Reference | .1877 | .102 |
| 2 | 568 (11%) | 0.921 | |||
| 3 | 448 (9%) | 0.672 | |||
| Other/Unknown | 910 (18%) | 0.902 | |||
| HIV co-infected | No | 4978 (97%) | Reference | .5969 | .468 |
| Yes | 149 (3%) | 1.144 | |||
| FIB4 | ≤1.21 | 898 (18%) | Reference | .0149 | .525 |
| 1.21–5.88 | 2258 (44%) | 1.56 | |||
| >5.88 | 468 (9%) | 1.709 | |||
| Unknown | 1503 (29%) | 1.58 | |||
| ALT levels (U/L) | <45 | 1178 (23%) | Reference | .079 | .901 |
| ≥45 | 2972 (58%) | 1.261 | |||
| Unknown | 977 (19%) | ||||
| Prior treatment | No | 3882 (76%) | Reference | .018 | .692 |
| Yes | 1245 (24%) | 1.297 | |||
| Multiple comorbidities | No | 3211 (63%) | Reference | .0035 | .084 |
| Yes | 1916 (37%) | 1.323 | |||
| Cirrhosis | No | 3750 (73%) | Reference | <.0001 | .216 |
| Yes | 1377 (27%) | 1.55 |
ASINPI, Asian American, American Indian, or Pacific Islander; BMI, body mass index; FIB4, Fibrosis- 4 Index; HCV, hepatitis C virus; SVR, sustained virologic response; T2D, type 2 diabetes mellitus.